Open AccessPhotonic crystal based microscale flow cytometry
Author(s) -
Justin Stewart,
Anna Pyayt
Publication year - 2014
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.22.012853
Subject(s) - microscale chemistry , photonic crystal , optics , materials science , photonics , flow cytometry , flow (mathematics) , signal (programming language) , optoelectronics , physics , mathematics , mathematics education , biology , computer science , mechanics , genetics , programming language
Here we propose a new design of an on-chip micro-flow cytometry based on photonic crystals. When individual cells flow tangential to the crystal surface, the transmission of the light through the photonic crystal changes depending on the presence or absence of the cells and their size and shape. This system was modeled using OptiFDTD, where transmission spectra were extracted. Initially, the potential for cell counting has been demonstrated. Then, for cells with differing shape a direct relation between signal distribution and cell shape has been found.