Open AccessHighly controllable synthesis of near-infrared persistent luminescence SiO_2/CaMgSi_2O_6 composite nanospheres for imaging in vivo
Author(s) -
Zhanjun Liu,
Junpeng Shi,
Hongwu Zhang,
Meng Sun
Publication year - 2014
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.22.010509
Subject(s) - luminescence , persistent luminescence , materials science , nanoparticle , in vivo , mesoporous material , preclinical imaging , nanotechnology , lymph , optoelectronics , chemistry , pathology , thermoluminescence , medicine , biology , microbiology and biotechnology , catalysis , biochemistry
High quality near-infrared (NIR) persistent luminescence nanospheres (PLNPs) were synthesized using a simple mesoporous template method. The as-synthesized NIR persistent luminescence nanoparticles have uniform spherical morphology, tunable sizes, and a nominal composition of SiO(2)/CaMgSi(2)O(6):Eu(2+), Pr(3+), Mn(2+) (denoted as SEPM). Their NIR persistent luminescence at 660 nm can be detected during more than 1 hour. The in vivo distribution of the nanoparticles in the abdomen can be detected in real time after injection into the abdomen of a mouse. The nanoparticles can be metabolized from the lymph circulation and transferred from the abdomen to the bladder. The results indicate an effective method to offer high quality NIR persistent luminescence nanoprobes for imaging.