Open AccessPhotoacoustic guided ultrasound wavefront shaping for targeted acousto-optic imaging
Author(s) -
Jacob Staley,
Erwin Hondebrink,
Wilma Peterson,
Wiendelt Steenbergen
Publication year - 2013
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.21.030553
Subject(s) - wavefront , optics , ultrasound , photoacoustic effect , photoacoustic imaging in biomedicine , photoacoustic doppler effect , materials science , detector , acoustics , signal (programming language) , transmission (telecommunications) , acoustic wave , physics , computer science , telecommunications , programming language
To overcome speed of sound aberrations that negatively impact the acoustic focus in acousto-optic imaging, received photoacoustic signals are used to guide the formation of ultrasound wavefronts to compensate for acoustic inhomogeneities. Photoacoustic point sources composed of gold and superparamagnetic iron oxide nanoparticles are used to generate acoustic waves that acoustically probe the medium as they propagate to the detector. By utilizing cross-correlation techniques with the received photoacoustic signal, transmitted ultrasound wavefronts compensate for the aberration, allowing for optimized and configurable ultrasound transmission to targeted locations. It is demonstrated that utilizing a portable commercially available ultrasound system using customized software, photoacoustic guided ultrasound wavefront shaping for targeted acousto-optic imaging is robust in the presence of large, highly attenuating acoustic aberration.