Open AccessHigh contrast three-dimensional photoacoustic imaging through scattering media by localized optical fluence enhancement
Author(s) -
Antonio M. Caravaca-Aguirre,
Donald B. Conkey,
Jacob D. Dove,
Hengyi Ju,
Todd W. Murray,
Rafael Piestun
Publication year - 2013
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.21.026671
Subject(s) - optics , wavefront , scattering , signal (programming language) , fluence , photoacoustic doppler effect , materials science , photoacoustic effect , light scattering , photoacoustic imaging in biomedicine , photoacoustic spectroscopy , physics , laser , computer science , programming language
We demonstrate enhanced three-dimensional photoacoustic imaging behind a scattering material by increasing the fluence in the ultrasound transducer focus. We enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the scattering medium serves as feedback to optimize the wavefront, enabling one order of magnitude enhancement of the photoacoustic amplitude. Using the enhanced optical intensity, we scan the object in two-dimensions before post-processing of the data to reconstruct the image. The temporal profile of the photoacoustic signal provides the information used to reconstruct the third dimension.