Portable, miniaturized, fibre delivered, multimodal CARS exoscope | Zendy

Brett Smith | Zendy; Majid Naji | Zendy; Sangeeta Murugkar | Zendy; Emilio I. Alarcón | Zendy; Craig Brideau | Zendy; Peter K. Stys | Zendy; Hanan Anis | Zendy

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Portable, miniaturized, fibre delivered, multimodal CARS exoscope

Author(s) -

Brett Smith,

Majid Naji,

Sangeeta Murugkar,

Emilio I. Alarcón,

Craig Brideau,

Peter K. Stys,

Hanan Anis

Publication year - 2013

Publication title -

optics express

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.21.017161

Subject(s) - optics , femtosecond , raman scattering , materials science , second harmonic generation , laser , raman spectroscopy , physics

We demonstrate for the first time, a portable multimodal coherent anti-Stokes Raman scattering microscope (exoscope) for minimally invasive in-vivo imaging of tissues. This device is based around a micro-electromechanical system scanning mirror and miniaturized optics with light delivery accomplished by a photonic crystal fibre. A single Ti:sapphire femtosecond pulsed laser is used as the light source to produce CARS, two photon excitation fluorescence and second harmonic generation images. The high resolution and distortion-free images obtained from various resolution and bio-samples, particularly in backward direction (epi) successfully demonstrate proof of concept, and pave the path towards future non or minimally-invasive in vivo imaging.

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