Open AccessPortable, miniaturized, fibre delivered, multimodal CARS exoscope
Author(s) -
Brett Smith,
Majid Naji,
Sangeeta Murugkar,
Emilio I. Alarcon,
Craig Brideau,
Peter K. Stys,
Hanan Anis
Publication year - 2013
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.21.017161
Subject(s) - optics , femtosecond , raman scattering , materials science , second harmonic generation , laser , raman spectroscopy , physics
We demonstrate for the first time, a portable multimodal coherent anti-Stokes Raman scattering microscope (exoscope) for minimally invasive in-vivo imaging of tissues. This device is based around a micro-electromechanical system scanning mirror and miniaturized optics with light delivery accomplished by a photonic crystal fibre. A single Ti:sapphire femtosecond pulsed laser is used as the light source to produce CARS, two photon excitation fluorescence and second harmonic generation images. The high resolution and distortion-free images obtained from various resolution and bio-samples, particularly in backward direction (epi) successfully demonstrate proof of concept, and pave the path towards future non or minimally-invasive in vivo imaging.