On-chip modulation of evanescent illumination and live-cell imaging with polymer waveguides | Zendy

Björn Agnarsson | Zendy; Ásta Björk Jónsdóttir | Zendy; Nína Björk Arnfinnsdóttir | Zendy; Kristján Leósson | Zendy

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On-chip modulation of evanescent illumination and live-cell imaging with polymer waveguides

Author(s) -

Björn Agnarsson,

Ásta Björk Jónsdóttir,

Nína Björk Arnfinnsdóttir,

Kristján Leósson

Publication year - 2011

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.19.022929

Subject(s) - optics , photobleaching , waveguide , materials science , interferometry , modulation (music) , total internal reflection , chip , optoelectronics , microscopy , excitation , live cell imaging , fluorescence , physics , chemistry , electrical engineering , quantum mechanics , acoustics , engineering , biochemistry , cell

Imaging of live cells was carried out using evanescent-wave excitation on a polymer waveguide chip. Integrated waveguide-based interferometric light modulators were fabricated in order to demonstrate on-chip control of excitation light, e.g., for time-lapse fluorescence microscopy. When combined with a sensitive high-resolution imaging system, the integrated waveguide-excitation platform provides an ideal method of near-surface studies of live cells, where photobleaching and/or phototoxicity effects are of critical concern.

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