Open AccessHigh-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model
Author(s) -
Hua Chen,
Te-Hsuen Chen,
TaiLin Tseng,
Jen-Tang Lu,
Chung-Chiu Kuo,
Shih-Chen Fu,
Wei-Jei Lee,
YungFong Tsai,
YiYou Huang,
Eric Y. Chuang,
Yuh-Jing Hwang,
ChiKuang Sun
Publication year - 2011
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.19.021552
Subject(s) - in vivo , preclinical imaging , breast cancer , terahertz radiation , cancer , human breast , medicine , materials science , pathology , biomedical engineering , biology , optoelectronics , microbiology and biotechnology
We performed in vivo THz transmission imaging study on a subcutaneous xenograft mouse model for early human breast cancer detection. With a THz-fiber-scanning transmission imaging system, we continuously monitored the growth of human breast cancer in mice. Our in vivo study not only indicates that THz transmission imaging can distinguish cancer from the surrounding fatty tissue, but also with a high sensitivity. Our in vivo study on the subcutaneous xenograft mouse model will encourage broad and further investigations for future early cancer screening by using THz imaging system.