Open AccessTargeted delivery and controllable release of nanoparticles using a defect-decorated optical nanofiber
Author(s) -
Hongbao Xin,
Baojun Li
Publication year - 2011
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.19.013285
Subject(s) - materials science , nanofiber , nanotechnology , nanoparticle , drug delivery , polystyrene , targeted drug delivery , optical power , optical force , optical fiber , optoelectronics , optical tweezers , laser , optics , composite material , polymer , physics
Targeted drug delivery and controllable release are particularly beneficial in medical therapy. This work provides a demonstration of nanoparticles targeted delivery and controllable release using a defect-decorated optical nanofiber (NF). By using the NF, polystyrene particles (PSs) (713-nm diameter) suspended in water were successfully trapped, then delivered along the NF at an average velocity of 4.8 µm/s with the assistance of a laser beam of 980-nm wavelength at an optical power of 39 mW, and finally, assembled at the defect. Subsequently, by turning off the optical power, 90% of the assembled PSs can be released in 30 s. This method would be useful in targeted drug delivery and controllable release, and provide potential applications in targeted therapy.