Open AccessFabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry
Author(s) -
Chi-Hsiang Lien,
Wen Shuo Kuo,
Keng Chi Cho,
Chun Yu Lin,
Yuan Deng Su,
Lynn Ling-Huei Huang,
Paul J. Campagnola,
Dong Chen,
Shean Jen Chen
Publication year - 2011
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.19.006260
Subject(s) - nanorod , materials science , photothermal therapy , bovine serum albumin , surface plasmon resonance , rose bengal , plasmon , microstructure , absorption (acoustics) , laser , optoelectronics , doping , optics , nanotechnology , nanoparticle , chemistry , composite material , physics , organic chemistry , biochemistry
In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30%. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.