Open AccessFabrication of glucose fiber sensor based on immobilized GOD technique for rapid measurement
Author(s) -
Ting-Qian Lin,
Yin-Lin Lu,
C. S. Hsu
Publication year - 2010
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.18.027560
Subject(s) - glucose oxidase , calibration curve , fiber optic sensor , biosensor , optical fiber , materials science , fiber , linearity , calibration , optics , resolution (logic) , interferometry , chromatography , analytical chemistry (journal) , chemistry , detection limit , nanotechnology , computer science , physics , composite material , quantum mechanics , artificial intelligence
The concentration and pH value of the immobilized glucose oxidase (GOD) are critical parameters in a glucose sensor. In this study, we develop a glucose fiber sensor integrated with heterodyne interferometry to measure the phase difference arising from the chemical reaction between glucose and GOD. Our studies show that the response time and resolution of this sensor will be strongly affected by the pH and concentration properties of GOD. In addition, the results show good linearity between the calibration curve for the glucose solution and serum based sample. The response time of this sensor can be shorter than 3 seconds and best resolutions are 0.1 and 0.136 mg/dl for glucose solution and serum based sample, respectively.