Angular domain fluorescence lifetime imaging: a tissue-like phantom study | Zendy

Mohamadreza Najiminaini | Zendy; Fartash Vasefi | Zendy; Kenneth M. Tichauer | Zendy; TingYim Lee | Zendy; Bożena Kamińska | Zendy; Jeffrey J. L. Carson | Zendy

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Angular domain fluorescence lifetime imaging: a tissue-like phantom study

Author(s) -

Mohamadreza Najiminaini,

Fartash Vasefi,

Kenneth M. Tichauer,

TingYim Lee,

Bożena Kamińska,

Jeffrey J. L. Carson

Publication year - 2010

Publication title -

optics express

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.18.023247

Subject(s) - pinhole (optics) , optics , imaging phantom , collimated light , lens (geology) , fluorescence , angular resolution (graph drawing) , image resolution , fluorescence lifetime imaging microscopy , materials science , physics , laser , mathematics , combinatorics

We describe a fluorescence lifetime imaging technique employing the collimation detection capabilities of an angular filter array (AFA). The AFA accepts minimally scattered photons emitted from fluorophores up to 2 mm deep within turbid media. The technique, referred to as Angular Domain Fluorescence Lifetime Imaging (ADFLI), is described and its performance evaluated in comparison to a conventional (lens and pinhole) system. Results from a tissue-mimicking phantom demonstrated that ADFLI provides better spatial resolution and image contrast for fluorescent probes at greater depths compared to a lens and pinhole system.

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