Open AccessReal-time cancellation of temperature induced resonance shifts in SOI wire waveguide ring resonator label-free biosensor arrays
Author(s) -
DanXia Xu,
Martin Vachon,
A. Densmore,
R. Ma,
Siegfried Janz,
A. Delâge,
J. Lapointe,
Pavel Cheben,
Jens H. Schmid,
E. Post,
S. Messaoudène,
Jean-Marc Fédéli
Publication year - 2010
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.18.022867
Subject(s) - resonator , cladding (metalworking) , biosensor , materials science , silicon on insulator , refractive index , response time , temperature measurement , atmospheric temperature range , optoelectronics , resonance (particle physics) , dynamic range , optics , temperature coefficient , silicon , nanotechnology , composite material , physics , atomic physics , computer graphics (images) , quantum mechanics , computer science , meteorology
A comprehensive investigation of real-time temperature-induced resonance shift cancellation for silicon wire based biosensor arrays is reported for the first time. A reference resonator, protected by either a SU8 or SiO(2) cladding layer, is used to track temperature changes. The temperature dependence of resonators in aqueous solutions, pertinent to biosensing applications, is measured under steady-state conditions and the operating parameters influencing these properties are discussed. Real-time measurements show that the reference resonator resonances reflect the temperature changes without noticeable time delay, enabling effective cancellation of temperature-induced shifts. Binding between complementary IgG protein pairs is monitored over 4 orders of magnitude dynamic range down to a concentration of 20 pM, demonstrating a resolvable mass of 40 attograms. Reactions are measured over time periods as long as 3 hours with high stability, showing a scatter corresponding to a fluid refractive index fluctuation of ± 4 × 10(-6) in the baseline data. Sensor arrays with a SU8 protective cladding are easy to fabricate, while oxide cladding is found to provide superior stability for measurements involving long time scales.