Open AccessQuantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints
Author(s) -
Jiaying Xiao,
Lei Yao,
Yao Sun,
Eric S. Sobel,
Juan He,
Huabei Jiang
Publication year - 2010
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.18.014359
Subject(s) - osteoarthritis , photoacoustic imaging in biomedicine , tomography , photoacoustic tomography , cartilage , finger joint , attenuation coefficient , quantitative computed tomography , materials science , biomedical engineering , medicine , nuclear medicine , optics , anatomy , radiology , pathology , bone density , physics , alternative medicine , osteoporosis , composite material
We present for the first time in vivo experimental evidence that quantitative photoacoustic tomography (qPAT) has the potential to detect osteoarthritis (OA) in the finger joints. In this pilot study, 2 OA patients and 4 healthy volunteers were enrolled, and their distal interphalangeal (DIP) joints were examined photoacoustically by a PAT scanner. Tissue absorption coefficient images of all the examined joints, which were unavailable from the conventional PAT, were recovered using our finite element based qPAT approach. The recovered quantitative photoacoustic images revealed significant differences in the tissue absorption coefficient of the joint cavity (cartilage and synovial fluid) between the OA and normal joints.