Open AccessUltrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds
Author(s) -
Lin An,
Jia Qin,
Ke Wang
Publication year - 2010
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.18.008220
Subject(s) - microangiography , human skin , blood flow , biomedical engineering , dermis , capillary action , optics , angiography , preclinical imaging , materials science , medicine , in vivo , pathology , radiology , biology , physics , genetics , microbiology and biotechnology , composite material
In this paper, we demonstrate for the first time that the detailed cutaneous blood flow at capillary level within dermis of human skin can be imaged by optical micro-angiography (OMAG) technique. A novel scanning protocol, i.e. fast B scan mode is used to achieve the capillary flow imaging. We employ a 1310nm system to scan the skin tissue at an imaging rate of 300 frames per second, which requires only ~5 sec to complete one 3D imaging of capillary blood flow within skin. The technique is sensitive enough to image the very slow blood flows at ~4 microm/sec. The promising results show a great potential of OMAG's role in the diagnosis, treatment and management of human skin diseases.