Open AccessAdaptive improved element free Galerkin method for quasi- or multi-spectral bioluminescence tomography
Author(s) -
Chenghu Qin,
Xin Yang,
Jinchao Feng,
Kai Li,
Junting Liu,
Guorui Yan,
Shouping Zhu,
Min Xu,
Jie Tian
Publication year - 2009
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.17.021925
Subject(s) - a priori and a posteriori , imaging phantom , galerkin method , computer science , tomography , optical tomography , finite element method , iterative reconstruction , diffuse optical imaging , optics , computer vision , physics , philosophy , epistemology , thermodynamics
Bioluminescence tomography (BLT) has become a powerful tool for whole-body small animal imaging. In this contribution, an adaptive improved element free Galerkin method (IEFGM) is presented to perform a quantitative reconstruction of the internal light source using quasi- or multi-spectral information, which not only can avoid the time-consuming mesh generation but also can reduce the ill-posedness of BLT effectively. In the algorithm, the reconstruction can be largely enhanced by an adaptive technology based on a posteriori error estimation. Finally, the numerical and physical phantom experiment results show that the bioluminescent source can be recovered accurately.