Open AccessMultispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging
Author(s) -
Rui Ma,
Adrian Taruttis,
Vasilis Ntziachristos,
Daniel Razansky
Publication year - 2009
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.17.021414
Subject(s) - multispectral image , imaging phantom , tomography , scanner , optics , molecular imaging , whole body imaging , data acquisition , signal to noise ratio (imaging) , biomedical engineering , signal (programming language) , preclinical imaging , computer science , medical physics , computer vision , physics , in vivo , positron emission tomography , nuclear medicine , medicine , biology , microbiology and biotechnology , programming language , operating system
A major difficulty arising from whole-body optoacoustic imaging is the long acquisition times associated with recording signals from multiple spatial projections. The acquired signals are also generally weak and the signal-to-noise-ratio is low, problems often solved by signal averaging, which complicates acquisition and increases acquisition times to an extent that makes many in vivo applications challenging or even impossible. Herein we present a fast acquisition multispectral optoacoustic tomography (MSOT) scanner for whole-body visualization of molecular markers in small animals. Multi-wavelength illumination offers the possibility to resolve exogenously administered fluorescent probes, biomarkers, and other intrinsic and exogenous chromophores. The system performance is determined in phantom experiments involving molecular probes and validated by imaging of small animals of various scales.