Open AccessComparison of reflectivity maps and outer retinal topography in retinal disease by 3-D Fourier domain optical coherence tomography
Author(s) -
Maciej Wojtkowski,
Bartosz L. Sikorski,
Iwona Gorczyńska,
Michalina J. Gora,
Maciej Szkulmowski,
Danuta Bukowska,
Jakub J. Kałużny,
James G. Fujimoto,
Andrzej Kowalczyk
Publication year - 2009
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.17.004189
Subject(s) - optical coherence tomography , retinal , optics , thresholding , tomography , computer science , visualization , image processing , retina , coherence (philosophical gambling strategy) , artificial intelligence , physics , ophthalmology , medicine , image (mathematics) , quantum mechanics
We demonstrate and compare two image processing methods for visualization and analysis of three-dimensional optical coherence tomography (OCT) data acquired in eyes with different retinal pathologies. A method of retinal layer segmentation based on a multiple intensity thresholding algorithm was implemented in order to generate simultaneously outer retinal topography maps and reflectivity maps. We compare the applicability of the two methods to the diagnosis of retinal diseases and their progression. The data presented in this contribution were acquired with a high speed (25,000 A-scans/s), high resolution (4.5 microm) spectral OCT prototype instrument operating in the ophthalmology clinic.