Open AccessSensitive DNA biosensor based on a long-period grating formed on the side-polished fiber surface
Author(s) -
Hyun Soo Jang,
Kwang No Park,
Jun P. Kim,
Sang Jun Sim,
Oh Joon Kwon,
Young-Hee Han,
Kyung Shik Lee
Publication year - 2009
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.17.003855
Subject(s) - biosensor , materials science , grating , optics , biomolecule , wavelength , optical fiber , fiber , optoelectronics , nanotechnology , physics , composite material
We demonstrate a sensitive DNA biosensor based on a long period grating (LPG) formed by a photolithograph process on the surface of a side-polished fiber. The biomolecules of the biosensor were immobilized on the silica surface between LPG patterns. The resonance wavelength was red-shifted after the binding of the poly-L-lysine, probe ssDNA and target ssDNA to the sensor surface. The overall wavelength shift after the successful DNA hybridization was 1.82 nm. The proposed LPG-based DNA biosensor is approximately 2.5 times more sensitive than the previously reported fiber grating-based DNA biosensors.