Open AccessRealtime photoacoustic microscopy of murine cardiovascular dynamics.
Author(s) -
Roger J. Zemp,
Song Liu,
Rachel Bitton,
K. Kirk Shung,
L. V. Wang
Publication year - 2008
Publication title -
pubmed
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
eISSN - 1094-4087
DOI - 10.1364/oe.16.18551
Subject(s) - photoacoustic imaging in biomedicine , optics , laser , transducer , frame rate , ultrasound , materials science , visualization , temporal resolution , microscopy , image resolution , photoacoustic doppler effect , biomedical engineering , computer science , acoustics , physics , artificial intelligence , medicine
Non-invasive visualization of cardiovascular dynamics in small animals is challenging due to their rapid heart-rates. We present a realtime photoacoustic imaging system consisting of a 30-MHz ultrasound array transducer, receive electronics, a high-repetition-rate laser, and a multicore-computer, and demonstrate its ability to image optically-absorbing structures of the beating hearts of young athymic nude mice at rates of approximately 50 frames per second with 100 microm x 25 microm spatial resolution. To our knowledge this is the first report of realtime photoacoustic imaging of physiological dynamics.