Open AccessIn-vivo fluorescence imaging of mammalian organs using charge-assembled mesocapsule constructs containing indocyanine green
Author(s) -
Mohammad A. Yaseen,
Jie Yu,
Michael S. Wong,
Bahman Anvari
Publication year - 2008
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.16.020577
Subject(s) - indocyanine green , fluorescence , biodistribution , fluorescence lifetime imaging microscopy , in vivo , preclinical imaging , optical imaging , materials science , optics , biophysics , biomedical engineering , chemistry , medicine , biology , physics , microbiology and biotechnology
Indocyanine green (ICG) is a fluorescent probe used in clinical imaging. However, its utility remains limited by optical instability, rapid circulation kinetics, and exclusive uptake by the liver. Using mesocapsule (MC) constructs to encapsulate ICG, we have developed a technology to stabilize ICG's optical properties and alter its biodistribution. We present in vivo fluorescence images of mammalian organs to demonstrate the potential application of our ICG encapsulation technology for optical imaging of specific tissues.