Open AccessBiofunctionalized tilted Fiber Bragg Gratings for label-free immunosensing
Author(s) -
Séverine Maguis,
Guillaume Laffont,
Pierre Ferdinand,
Benjamin Carbonnier,
K. Kham,
Tahar Mekhalif,
MarieClaude Millot
Publication year - 2008
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.16.019049
Subject(s) - biosensor , fiber bragg grating , materials science , cladding (metalworking) , refractive index , biomolecule , optics , optical fiber , phosfos , grating , fiber optic sensor , fiber , optoelectronics , nanotechnology , graded index fiber , wavelength , physics , metallurgy , composite material
We present a study aimed at developing a label-free optical fiber biosensor for detection and quantification of biomolecules in real-time. The biosensor based on a Tilted Fiber Bragg Grating (TFBG) transduces a binding event between the probe and target molecules into a change in the refractive index of the medium surrounding the fiber. This work describes the experimental results obtained with three methods for immobilizing biomolecular probes on a TFBG silica cladding surface. Bovine serum albumin (BSA) and anti-BSA are used to assess the performances of the TFBG based biosensor in each configuration.