Open AccessFast time-domain diffuse optical tomography using pseudorandom bit sequences
Author(s) -
Wei Mo,
Nanguang Chen
Publication year - 2008
Publication title -
optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.16.013643
Subject(s) - optics , diffuse optical imaging , demodulation , pseudorandom number generator , time domain , signal (programming language) , imaging phantom , optical coherence tomography , picosecond , impulse response , computer science , physics , materials science , tomography , laser , algorithm , telecommunications , mathematics , channel (broadcasting) , mathematical analysis , computer vision , programming language
We report a novel time-domain diffuse optical tomography to determine the optical properties in a faster speed than the conventional ones. Instead of using the ultrashort pulse laser, a 2.5 Gbps pseudorandom bit sequence is used to modulate the near-infrared light for tissue-like phantom illumination. The time-resolved signal can be retrieved very quickly by demodulation with the reference signal. The system impulse response has a full width at half maximum around 800 picoseconds and the 2-dimentional maps of optical properties can be obtained within a few seconds. The high signal-to-noise ratio and the environmental illumination insensitivity warrant a great potential for applications in clinical noninvasive breast cancer detection.