Open AccessMonte Carlo algorithm for efficient simulation of time-resolved fluorescence in layered turbid media
Author(s) -
Adam Liebert,
Heidrun Wabnitz,
Norbert Żołek,
Rainer Macdonald
Publication year - 2008
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.16.013188
Subject(s) - monte carlo method , optics , photon , fluorescence , physics , scattering , detector , wavelength , excitation , diffusion , photon diffusion , fluorescence correlation spectroscopy , photon counting , materials science , mathematics , light source , statistics , quantum mechanics , thermodynamics
We present an efficient Monte Carlo algorithm for simulation of time-resolved fluorescence in a layered turbid medium. It is based on the propagation of excitation and fluorescence photon bundles and the assumption of equal reduced scattering coefficients at the excitation and emission wavelengths. In addition to distributions of times of arrival of fluorescence photons at the detector, 3-D spatial generation probabilities were calculated. The algorithm was validated by comparison with the analytical solution of the diffusion equation for time-resolved fluorescence from a homogeneous semi-infinite turbid medium. It was applied to a two-layered model mimicking intra- and extracerebral compartments of the adult human head.