Dynamics of femtosecond laser photo-modification of collagen fibers | Zendy

Vladimir Hovhannisyan | Zendy; Wen Lo | Zendy; Chieh Hu | Zendy; SheanJen Chen | Zendy; Dong Chen | Zendy

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Dynamics of femtosecond laser photo-modification of collagen fibers

Author(s) -

Vladimir Hovhannisyan,

Wen Lo,

Chieh Hu,

SheanJen Chen,

Dong Chen

Publication year - 2008

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.16.007958

Subject(s) - femtosecond , materials science , laser , autofluorescence , optics , second harmonic generation , confocal , surface modification , cornea , biophysics , fluorescence , chemistry , physics , biology

In this work, we investigate the non-ablative, non-thermal photo-modification of collagen fibers by femtosecond Ti:Sa laser. The effect was induced and simultaneously registered during the repetitive laser scanning of type I collagen (rat tail and bovine Achilles' tendon), and bovine cornea. An irreversible increase in two-photon autofluorescence and a decrease in second harmonic generation intensities were associated with the collagen femtosecond laser photo-modification. Confocal spectral imaging revealed the formation of new fluorescent species. Controllable nonlinear photo-modification of collagen fibers and bovine cornea with approximately 2 microm spatial resolution was demonstrated.

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