Open AccessInspiratory contrast for in vivo optical imaging
Author(s) -
Kenneth T. Kotz,
Sanhita Dixit,
Ashley D. Gibbs,
Juan Orduña,
Zishan A. Haroon,
Khalid Amin,
Gregory W. Faris
Publication year - 2007
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.16.000019
Subject(s) - preclinical imaging , in vivo , contrast (vision) , optical imaging , optics , cancer , materials science , biomedical engineering , pathology , medicine , biology , physics , microbiology and biotechnology
We demonstrate the use of inspired oxygen and carbon dioxide as a possible route to increase contrast in optical imaging of cancerous tissue. Differential imaging in human xenograft rodent models of cancer exhibits significant variation in signal between normal and cancerous tissue. This differential cancer-specific contrast is stronger and more consistent than the conventional static contrast. This differential technique exploits the response of abnormal tumor vasculature to inhaled gases and could provide a promising alternative to supplement mainstream cancer imaging modalities such as x-rays and MRI.