Open AccessInvariant resolution dynamic focus OCM based on liquid crystal lens
Author(s) -
Supraja Murali,
K. S. Lee,
Jannick P. Rolland
Publication year - 2007
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.15.015854
Subject(s) - optics , optical coherence tomography , numerical aperture , lens (geology) , materials science , focal length , microscope , liquid crystal , holography , depth of focus (tectonics) , microscopy , coherence (philosophical gambling strategy) , physics , wavelength , paleontology , subduction , biology , tectonics , quantum mechanics
A primary limitation of optical coherence microscopy is the lack of sufficient lateral resolution over a usable imaging volume for diagnostic applications, even with high-numerical aperture imaging optics. In this paper, we first motivate the benefit of refocusing at multiple depths in a highly scattering biological sample using optical coherence microscopy, which experimentally shows invariant 2.5 mum axial and 6.5 mum lateral resolution throughout the sample. We then present the optical system design of a hand-held probe with the advanced capability to dynamically focus with no moving parts to a depth of 2 mm in skin-equivalent tissue at 3 mum resolution throughout an 8 cubic millimeter imaging volume. The built-in dynamic focusing ability is investigated with an addressable liquid crystal lens embedded in a custom-designed optics optimized for a Ti:Sa pulsed broadband laser source of bandwidth 100nm centered at 800nm. The design was developed not only to account for refocusing into the tissue but also to minimize and compensate for the varying on-axis and off-axis optical aberrations that would be introduced throughout a 2 mm thick and 2 mm wide skin imaging volume. The MTF contrast functions and distortion plots at three different skin depths are presented.