Open AccessQuantitative measurement of muscle oxygen saturation without influence from skin and fat using continuous-wave near infrared spectroscopy
Author(s) -
Yong Yang,
Olusola O. Soyemi,
P. J. Scott,
Michelle Landry,
Stuart M. C. Lee,
Leah Stroud,
Babs R. Soller
Publication year - 2007
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.15.013715
Subject(s) - materials science , optics , attenuation coefficient , scattering , repeatability , near infrared spectroscopy , spectroscopy , attenuation , spectral line , biomedical engineering , analytical chemistry (journal) , chemistry , physics , medicine , chromatography , quantum mechanics , astronomy
A method to non-invasively and quantitatively measure muscle oxygen saturation (SmO(2)) using broadband continuous-wave diffuse reflectance near infrared (NIR) spectroscopy is presented. The method obtained SmO(2) by first correcting NIR spectra for absorption and scattering of skin pigment and fat, then fitting to a Taylor expansion attenuation model. A non-linear least squares optimization algorithm with set boundary constraints on the fitting parameters was used to fit the model to the acquired spectra. A data preprocessing/optimization scheme for accurately determining the initial values needed for the optimization was also employed. The method was evaluated on simulated muscle spectra with 4 different scattering properties, as well as on in vivo forearm spectra from 5 healthy volunteer subjects during arterial occlusion. Measurement repeatability was assessed on 24 healthy volunteers with 5 repeated measurements, each separated by at least 48 hours.