Open AccessIncreased optical contrast in imaging of epidermal growth factor receptor using magnetically actuated hybrid gold/iron oxide nanoparticles
Author(s) -
Jesse Aaron,
Junghwan Oh,
Timothy Larson,
Sonia Kumar,
Thomas E. Milner,
Konstantin Sokolov
Publication year - 2006
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.14.012930
Subject(s) - materials science , superparamagnetism , surface plasmon resonance , colloidal gold , iron oxide nanoparticles , nanoparticle , iron oxide , plasmon , optics , nanotechnology , epidermal growth factor receptor , light scattering , optoelectronics , nuclear magnetic resonance , scattering , chemistry , magnetic field , magnetization , receptor , physics , biochemistry , quantum mechanics , metallurgy
We describe a new approach for optical imaging that combines the advantages of molecularly targeted plasmonic nanoparticles and magnetic actuation. This combination is achieved through hybrid nanoparticles with an iron oxide core surrounded by a gold layer. The nanoparticles are targeted in-vitro to epidermal growth factor receptor, a common cancer biomarker. The gold portion resonantly scatters visible light giving a strong optical signal and the superparamagnetic core provides a means to externally modulate the optical signal. The combination of bright plasmon resonance scattering and magnetic actuation produces a dramatic increase in contrast in optical imaging of cells labeled with hybrid gold/iron oxide nanoparticles.