In vivo nonlinear spectral imaging in mouse skin | Zendy

Jonathan A. Palero | Zendy; Henriëtte S. de Bruijn | Zendy; A. van der Ploeg–van den Heuvel | Zendy; Henricus J. C. M. Sterenborg | Zendy; Hans C. Gerritsen | Zendy

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In vivo nonlinear spectral imaging in mouse skin

Author(s) -

Jonathan A. Palero,

Henriëtte S. de Bruijn,

A. van der Ploeg–van den Heuvel,

Henricus J. C. M. Sterenborg,

Hans C. Gerritsen

Publication year - 2006

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.14.004395

Subject(s) - autofluorescence , optics , spectral imaging , microscopy , second harmonic generation , materials science , wavelength , imaging spectroscopy , medical imaging , spectroscopy , fluorescence , physics , laser , computer science , artificial intelligence , quantum mechanics

We report on two-photon autofluorescence and second harmonic spectral imaging of live mouse tissues. The use of a high sensitivity detector and ultraviolet optics allowed us to record razor-sharp deep-tissue spectral images of weak autofluorescence and short-wavelength second harmonic generation by mouse skin. Real-color image representation combined with depth-resolved spectral analysis enabled us to identify tissue structures. The results show that linking nonlinear deep-tissue imaging microscopy with autofluorescence spectroscopy has the potential to provide important information for the diagnosis of skin tissues.

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