Open AccessMultimodal near infrared spectral imaging as an exploratory tool for dysplastic esophageal lesion identification
Author(s) -
Chad A. Lieber,
Shiro Urayama,
Nazir Rahim,
Raymond H. Tu,
Ramez M. G. Saroufeem,
Boris Reubner,
Stavros G. Demos
Publication year - 2006
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.14.002211
Subject(s) - spectral imaging , optics , lesion , infrared , scattering , optical imaging , fluorescence lifetime imaging microscopy , fluorescence , materials science , radiology , pathology , medicine , physics
We explore nine different combinations of fluorescence, light scattering, and polarization spectral imaging approaches in the near-infrare spectral region toward the diagnosis of pathologic and normal esophageal lesions. The combinations of all the imaging techniques were evaluated for maximal sensitivity and specificity. The results suggest that this multimodal approach is capable of highly accurate detection of the presence of pathologic tissue.