Time-resolved spectrally constrained method for the quantification of chromophore concentrations and scattering parameters in diffusing media | Zendy

Cosimo D’Andrea | Zendy; Lorenzo Spinelli | Zendy; Andrea Bassi | Zendy; Arianna Giusto | Zendy; Davide Contini | Zendy; Johannes Swartling | Zendy; Alessandro Torricelli | Zendy; Rinaldo Cubeddu | Zendy

Open Access

Time-resolved spectrally constrained method for the quantification of chromophore concentrations and scattering parameters in diffusing media

Author(s) -

Cosimo D’Andrea,

Lorenzo Spinelli,

Andrea Bassi,

Arianna Giusto,

Davide Contini,

Johannes Swartling,

Alessandro Torricelli,

Rinaldo Cubeddu

Publication year - 2006

Publication title -

optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 271

ISSN - 1094-4087

DOI - 10.1364/oe.14.001888

Subject(s) - supercontinuum , optics , materials science , scattering , photon counting , light scattering , photonic crystal fiber , chromophore , photon diffusion , broadband , photon , optical fiber , physics , light source , quantum mechanics

We have devised and experimentally validated, on tissue-simulating phantoms and in vivo, a time-resolved spectral fitting analysis for direct assessment of chromophore concentrations and scattering parameters. Experimental data have been acquired with a time-resolved broadband system based on supercontinuum light generated in a photonic crystal fiber and a 32 channel Time Correlated Single Photon Counting system. The novel method is more robust than conventional techniques, especially at low signal-to-noise ratio.

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