Open AccessIn vivo size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography
Author(s) -
J. Armstrong,
Matthew S. Leigh,
Ian D. Walton,
Andrei V. Zvyagin,
Sergey Alexandrov,
S. Schwer,
David D. Sampson,
David R. Hillman,
Peter R. Eastwood
Publication year - 2003
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.11.001817
Subject(s) - optical coherence tomography , optics , airway , tomography , coherence (philosophical gambling strategy) , preclinical imaging , physics , in vivo , biology , quantum mechanics , microbiology and biotechnology , meteorology
We describe a long-range optical coherence tomography system for size and shape measurement of large hollow organs in the human body. The system employs a frequency-domain optical delay line of a configuration that enables the combination of high-speed operation with long scan range. We compare the achievable maximum delay of several delay line configurations, and identify the configurations with the greatest delay range. We demonstrate the use of one such long-range delay line in a catheter-based optical coherence tomography system and present profiles of the human upper airway and esophagus in vivo with a radial scan range of 26 millimeters. Such quantitative upper airway profiling should prove valuable in investigating the pathophysiology of airway collapse during sleep (obstructive sleep apnea).