Open AccessComplementary use of cross-polarization and standard OCT for differential diagnosis of pathological tissues
Author(s) -
Roman V. Kuranov,
Veronika V. Sapozhnikova,
Ilya V. Turchin,
Е. В. Загайнова,
Valentin M. Gelikonov,
Vladislav A. Kamensky,
Ludmila B. Snopova,
Natalia N. Prodanetz
Publication year - 2002
Publication title -
optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 271
ISSN - 1094-4087
DOI - 10.1364/oe.10.000707
Subject(s) - optical coherence tomography , optics , biological tissue , interferometry , materials science , polarization (electrochemistry) , biomedical engineering , physics , medicine , chemistry
An experimental standard optical coherence tomography (OCT) setup that can be easily modified for cross-polarization OCT (CP OCT) operation has been developed to perform differential diagnosis of pathological tissues. The complementary use of CP OCT, a technique that provides a map of cross-polarization backscattering properties of an object being studied by means of low-coherence interferometry, and standard OCT imaging improves the specificity of diagnostics of pathological changes occurring in tissues. It is shown that healthy, neoplastic and scar tissues of the esophagus have different cross-polarization backscattering properties. A comparative analysis of CP OCT, OCT and histological images from one and the same tissue area has been made. A close correlation between the location of collagen fibers in biological tissue and signal intensity in CP OCT images is found.