Open AccessScattering-independent glucose absorption measurement using a spectrally resolved reflectance setup with specialized variable source-detector separations
Author(s) -
Jin Liu,
Caigang Zhu,
Jingying Jiang,
Kexin Xu
Publication year - 2018
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.9.005903
Subject(s) - scattering , optics , radiative transfer , absorption (acoustics) , detector , monte carlo method , materials science , imaging phantom , attenuation coefficient , diffuse reflection , integrating sphere , physics , mathematics , statistics
We report a novel approach for the accurate measurement of glucose absorption in turbid media using a spectrally resolved reflectance setup. Our proposed reflectance setup with specialized variable source-detector separations enables scattering-independent absorption measurement, which is critical to in vivo long-term glucose concentration monitoring. Starting from the first-order approximation of the radiative transfer equation (RTE), we developed a scattering-independent glucose absorption measurement method and then evaluated this approach by Monte Carlo simulations as well as tissue-mimicking phantom studies in which glucose concentration was accurately measured. Our study demonstrates the potential of our proposed scattering-independent absorption measurement technique as an effective tool to quantify glucose levels in turbid media, which is an important step towards future in vivo long-term glucose concentration monitoring in human subjects.