Open AccessStable tissue-simulating phantoms with various water and lipid contents for diffuse optical spectroscopy
Author(s) -
Etsuko Ohmae,
Noriko Yoshizawa,
Kenji Yoshimoto,
Maho Hayashi,
Hiroko Wada,
Takashi Mimura,
Hiroaki Suzuki,
Shu Homma,
Norihiro Suzuki,
Hironao Ogura,
Hatsuko Nasu,
Harumi Sakahara,
Yutaka Yamashita,
Yoshihiro Ueda
Publication year - 2018
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.9.005792
Subject(s) - imaging phantom , diffuse optical imaging , materials science , spectroscopy , absorption (acoustics) , optics , diffuse reflectance infrared fourier transform , nuclear magnetic resonance , biomedical engineering , light scattering , magnetic resonance imaging , diffuse reflection , scattering , chemistry , tomography , physics , medicine , biochemistry , quantum mechanics , photocatalysis , composite material , catalysis , radiology
We introduced a method for producing solid phantoms with various water-to-lipid ratios that can simulate the absorption, and to some extent the scattering characteristics of human breast tissue. We also achieved phantom stability for a minimum of one month by solidifying the emulsion phantoms. The characteristics of the phantoms were evaluated using the six-wavelength time-domain diffuse optical spectroscopy (TD-DOS) system we developed to measure water and lipid contents and hemoglobin concentration. The TD-DOS measurements were validated with a magnetic resonance imaging system.