Stable tissue-simulating phantoms with various water and lipid contents for diffuse optical spectroscopy | Zendy

Etsuko Ohmae | Zendy; Nobuko Yoshizawa | Zendy; Kenji Yoshimoto | Zendy; Maho Hayashi | Zendy; Hiroko Wada | Zendy; T. Mimura | Zendy; Hiroaki Suzuki | Zendy; Shu Homma | Zendy; Norihiro Suzuki | Zendy; Hiroyuki Ogura | Zendy; Hatsuko Nasu | Zendy; Harumi Sakahara | Zendy; Yutaka Yamashita | Zendy; Yukio Ueda | Zendy

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Stable tissue-simulating phantoms with various water and lipid contents for diffuse optical spectroscopy

Author(s) -

Etsuko Ohmae,

Nobuko Yoshizawa,

Kenji Yoshimoto,

Maho Hayashi,

Hiroko Wada,

T. Mimura,

Hiroaki Suzuki,

Shu Homma,

Norihiro Suzuki,

Hiroyuki Ogura,

Hatsuko Nasu,

Harumi Sakahara,

Yutaka Yamashita,

Yukio Ueda

Publication year - 2018

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.9.005792

Subject(s) - imaging phantom , diffuse optical imaging , materials science , spectroscopy , optics , absorption (acoustics) , diffuse reflectance infrared fourier transform , nuclear magnetic resonance , diffuse reflection , light scattering , biomedical engineering , scattering , chemistry , tomography , physics , medicine , biochemistry , quantum mechanics , photocatalysis , catalysis , composite material

We introduced a method for producing solid phantoms with various water-to-lipid ratios that can simulate the absorption, and to some extent the scattering characteristics of human breast tissue. We also achieved phantom stability for a minimum of one month by solidifying the emulsion phantoms. The characteristics of the phantoms were evaluated using the six-wavelength time-domain diffuse optical spectroscopy (TD-DOS) system we developed to measure water and lipid contents and hemoglobin concentration. The TD-DOS measurements were validated with a magnetic resonance imaging system.

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