Open AccessNear-infrared probe-based confocal microendoscope for deep-tissue imaging
Author(s) -
Jiafu Wang,
Hua Li,
Geng Tian,
Yong Deng,
Qian Liu,
Ling Fu
Publication year - 2018
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.9.005011
Subject(s) - confocal , endoscope , optics , image quality , biomedical engineering , infrared , confocal microscopy , laser , near infrared spectroscopy , materials science , computer science , artificial intelligence , physics , medicine , radiology , image (mathematics)
In this work, a near-infrared probe-based confocal microendoscope (pCM) with a 785 nm laser source, a long working distance, and a probe with diameter of 2.6 mm that can be compatible with a conventional endoscope is demonstrated to produce deep-tissue images at cellular resolutions with enhanced contrast and signal-to-noise ratio. Theoretical simulations and experiments confirm that near-infrared light can optimize the image quality. Abundant details of mouse esophagus obtained at different depths demonstrate the system's ability to image deep tissues at cellular resolutions, which makes it possible to diagnose diseases in the digestive tract in real time, laying a solid foundation for clinical applications.