Open AccessClinical prototype of pigment and flow imaging optical coherence tomography for posterior eye investigation
Author(s) -
Shuichi Makita,
Toshihiro Mino,
Tastuo Yamaguchi,
Mashiro Miura,
Shinnosuke Azuma,
Yoshiaki Yasuno
Publication year - 2018
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.9.004372
Subject(s) - optical coherence tomography , decorrelation , optics , tomography , computer science , biomedical engineering , medical imaging , materials science , physics , computer vision , artificial intelligence , medicine
Measurements of the randomness of polarization (RP) obtained using polarization-sensitive optical coherence tomography (PS-OCT) are applied in several applications, and RP is attractive for posterior eye imaging. The addition of RP without retardation requires a minimal extension to standard OCT; therefore, we developed a prototype OCT system with a simplified scheme for RP measurement. A compact polarization-diversity receiver module is the only required hardware extension to a standard OCT system. All components were packed into the retinal scanning head. The degree-of-polarization uniformity and complex-decorrelation based OCT angiography were calculated using noise-corrected algorithms that accounted for the depth-dependent noise power. The structure, melanin, and blood flow distribution imaging of in vivo human eyes were demonstrated. Pathological eye imaging shows potential applications for combinations of these contrasts.