Open AccessFeasibility of using optical coherence tomography to detect radiation-induced fibrosis and residual cancer extent after neoadjuvant chemo-radiation therapy: an ex vivo study
Author(s) -
Pouya Jelvehgaran,
Tanja Alderliesten,
Giota Georgiou,
Sybren L. Meijer,
Paul R. Bloemen,
Liudmila L. Kodach,
Hanneke W. M. van Laarhoven,
Mark I. van Berge Henegouwen,
Maarten C.C.M. Hulshof,
Coen R. N. Rasch,
Ton G. van Leeuwen,
Johannes F. de Boer,
Martijn de Bruin,
Marcel van Herk
Publication year - 2018
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.9.004196
Subject(s) - esophageal cancer , medicine , esophagectomy , optical coherence tomography , radiation therapy , neoadjuvant therapy , histopathology , ex vivo , cancer , radiology , fibrosis , pathology , nuclear medicine , in vivo , breast cancer , microbiology and biotechnology , biology
Treatment of resectable esophageal cancer includes neoadjuvant chemo-radiation therapy (nCRT) followed by esophagectomy in operable patients. High-risk surgery may have been avoided in patients with a pathological complete response (pCR). We investigated the feasibility of optical coherence tomography (OCT) to detect residual cancer and radiation-induced fibrosis in 10 esophageal cancer patients that underwent nCRT followed by esophagectomy. We compared our OCT findings with histopathology. Overall, OCT was able to differentiate between healthy tissue, fibrotic tissue, and residual cancer with a sensitivity and specificity of 79% and 67%, respectively. Hence, OCT has the potential to add to the assessment of a pCR.