Selective delivery of laser energy to ester bonds of triacylglycerol in lipid droplets of adipocyte using a quantum cascade laser | Zendy

Noritaka Masaki | Zendy; Shigetoshi Okazaki | Zendy

Open Access

Selective delivery of laser energy to ester bonds of triacylglycerol in lipid droplets of adipocyte using a quantum cascade laser

Author(s) -

Noritaka Masaki,

Shigetoshi Okazaki

Publication year - 2018

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.9.002095

Subject(s) - laser , cascade , materials science , optics , laser light , adipocyte , nanotechnology , chemistry , optoelectronics , physics , biochemistry , chromatography , adipose tissue

The recent development of quantum cascade lasers (QCLs) has facilitated the irradiation of a mid-infrared laser beam that is specifically absorbed by a target molecular bond. Aiming for a selective delivery of laser energy to a specific absorption at 1,738 cm -1 by the ester bonds of triacylglycerol (TAG), a QCL beam with a wavenumber of 1,710 cm -1 was irradiated to 3T3-L1 adipocytes and preadipocytes. Neutral red staining, and FITC-labeled annexin V and ethidium homodimer-III assays revealed the occurrence of adipocyte-specific cell death 24 h after QCL irradiation. The selective delivery of laser energy to endogenous molecules can affect biological processes in a living organism.

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