Automated spectroscopic retinal oximetry with visible-light optical coherence tomography | Zendy

Shaohua Pi | Zendy; Acner Camino | Zendy; William O. Cepurna | Zendy; Xiang Wei | Zendy; Miao Zhang | Zendy; David Huang | Zendy; John C. Morrison | Zendy; Yali Jia | Zendy

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Automated spectroscopic retinal oximetry with visible-light optical coherence tomography

Author(s) -

Shaohua Pi,

Acner Camino,

William O. Cepurna,

Xiang Wei,

Miao Zhang,

David Huang,

John C. Morrison,

Yali Jia

Publication year - 2018

Publication title -

biomedical optics express

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.9.002056

Subject(s) - optical coherence tomography , retinal , pulse oximetry , reproducibility , oxygen saturation , biomedical engineering , optics , ophthalmology , medicine , materials science , oxygen , chemistry , anesthesia , physics , chromatography , organic chemistry

Accurate, quantitative assessment of retinal blood oxygen saturation ( sO 2 ) may provide a useful early indicator of pathophysiology in several ocular diseases. Here, with visible-light optical coherence tomography (OCT), we demonstrate an automated spectroscopic retinal oximetry algorithm to measure the sO 2 within the retinal arteries (A- sO 2 ) and veins (V- sO 2 ) in rats by automatically detecting the vascular posterior boundary on cross-sectional structural OCT. The algorithm was validated in vitro with flow phantoms and in vivo in rats by comparing the sO 2 results, respectively, to those obtained using a blood gas analyzer and pulse oximetry. We also investigated the response of oxygen extraction (A-V sO 2 ), including inter-session reproducibility, at different inhaled oxygen concentrations.

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