Open AccessCombination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages
Author(s) -
Ping Hisen Chen,
Chien Hsien Wu,
Yi Fen Chen,
Yi Chen Yeh,
Bo Lin,
Kuo Wei Chang,
Pei Yu Lai,
Ming Hou,
Ching Liang Lu,
Wen Chuan Kuo
Publication year - 2018
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.9.001461
Subject(s) - optical coherence tomography , pathology , dysplasia , malignancy , carcinoma in situ , lamina propria , medicine , hyperplasia , oral mucosa , epithelium , carcinogenesis , histology , cancer , carcinoma , radiology
Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was observed during cancer development in a 4- nitroquinoline-1-oxide (4NQO) mouse model. At the same time, microvascular changes in hyperplasia, dysplasia, carcinoma in situ and advanced cancer were observed. Findings from OCT imaging were compared with histology.