Open AccessGlycerol dehydration of native and diabetic animal tissues studied by THz-TDS and NMR methods
Author(s) -
O. A. Smolyanskaya,
Irina Schelkanova,
Maksim S. Kulya,
E. L. Odlyanitskiy,
I. S. Goryachev,
Anton Tcypkin,
Ya. V. Grachev,
Yana Toropova,
Valery V. Tuchin
Publication year - 2018
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.9.001198
Subject(s) - terahertz radiation , materials science , refractive index , penetration depth , dielectric , glycerol , refraction , absorption (acoustics) , penetration (warfare) , optics , nuclear magnetic resonance , optoelectronics , chemistry , composite material , organic chemistry , physics , operations research , engineering
The optical clearing method has been widely used for different spectral ranges where it provides tissue transparency. In this work, we observed the enhanced penetration of the terahertz waves inside biological samples (skin, kidney, and cornea) treated with glycerol solutions inducing changes of optical and dielectric properties. It was supported by the observed trend of free-to-bound water ratio measured by the nuclear magnetic resonance (NMR) method. The terahertz clearing efficiency was found to be less for diabetic samples than for normal ones. Results of the numerical simulation proved that pulse deformation is due to bigger penetration depth caused by the reduction of absorption and refraction at optical clearing.