Open AccessSpatially resolved diffuse reflectance spectroscopy endoscopic sensing with custom Si photodetectors
Author(s) -
Ben LaRiviere,
Katherine S. Garman,
N. Lynn Ferguson,
Deborah A. Fisher,
N.M. Jokerst
Publication year - 2018
Publication title -
biomedical optics express
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.9.001164
Subject(s) - diffuse reflectance infrared fourier transform , diffuse reflection , photodetector , materials science , optics , spectroscopy , diffuse optical imaging , reflectivity , optoelectronics , chemistry , physics , tomography , photocatalysis , biochemistry , quantum mechanics , catalysis
Early detection and surveillance of disease progression in epithelial tissue is key to improving long term patient outcomes for colon and esophageal cancers, which account for nearly a quarter of cancer related mortalities worldwide. Spatially resolved diffuse reflectance spectroscopy (SRDRS) is a non-invasive optical technique to sense biological changes at the cellular and sub-cellular level that occur when normal tissue becomes diseased, and has the potential to significantly improve the current standard of care for endoscopic gastrointestinal (GI) screening. Herein the design, fabrication, and characterization of the first custom SRDRS device to enable endoscopic SRDRS GI tissue characterization using a custom silicon (Si) thin film multi-pixel endoscopic optical sensor (MEOS) is described.