Application of a near-infrared laser tweezers Raman spectroscopy system for label-free analysis and differentiation of diabetic red blood cells | Zendy

Jinyong Lin | Zendy; Lingdong Shao | Zendy; Sufang Qiu | Zendy; Xingwu Huang | Zendy; Mengmeng Liu | Zendy; Zuci Zheng | Zendy; Duo Lin | Zendy; Yongliang Xu | Zendy; Zhihua Li | Zendy; Yao Lin | Zendy; Rong Chen | Zendy; Shangyuan Feng | Zendy

Open Access

Application of a near-infrared laser tweezers Raman spectroscopy system for label-free analysis and differentiation of diabetic red blood cells

Author(s) -

Jinyong Lin,

Lingdong Shao,

Sufang Qiu,

Xingwu Huang,

Mengmeng Liu,

Zuci Zheng,

Duo Lin,

Yongliang Xu,

Zhihua Li,

Yao Lin,

Rong Chen,

Shangyuan Feng

Publication year - 2018

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.9.000984

Subject(s) - raman spectroscopy , optical tweezers , spectroscopy , hemoglobin , laser , linear discriminant analysis , tweezers , diabetes mellitus , chemistry , materials science , medicine , optics , physics , biochemistry , computer science , endocrinology , artificial intelligence , quantum mechanics

A home-made near-infrared laser tweezers Raman spectroscopy (LTRS) system was applied to detect hemoglobin variation in red blood cells (RBCs) from diabetes without exogenous labeling. Results showed significant spectral differences existed between the diabetic and normal RBCs, including the peaks dominated by protein components (e.g. 1003 cm -1 ) and heme groups (e.g. 753 cm -1 ) in RBCs, and accurate classification results for diabetes detection were obtained by linear discriminant analysis with 100% sensitivity (i.e. no false negatives in the study). This work indicated the great promise of LTRS as a label-free RBC analytical tool for improving the accurate detection of type II diabetes.

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