Open AccessCerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects
Author(s) -
Giacomo Giacalone,
Marta Zanoletti,
Davide Contini,
Rebecca Re,
Lorenzo Spinelli,
Luisa Roveri,
Alessandro Torricelli
Publication year - 2017
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.8.004987
Subject(s) - reproducibility , deoxygenated hemoglobin , hemoglobin , saturation (graph theory) , nuclear magnetic resonance , oxygen saturation , near infrared spectroscopy , biomedical engineering , analytical chemistry (journal) , materials science , oxygen , nuclear medicine , medicine , cardiology , chemistry , optics , mathematics , chromatography , physics , organic chemistry , combinatorics
The reproducibility of cerebral time-domain near-infrared spectroscopy (TD-NIRS) has not been investigated so far. Besides, reference intervals of cerebral optical properties, of absolute concentrations of deoxygenated-hemoglobin (HbR), oxygenated-hemoglobin (HbO), total hemoglobin (HbT) and tissue oxygen saturation (StO 2 ) and their variability have not been reported. We have addressed these issues on a sample of 88 adult healthy subjects. TD-NIRS measurements at 690, 785, 830 nm were fitted with the diffusion model for semi-infinite homogenous media. Reproducibility, performed on 3 measurements at 5 minutes intervals, ranges from 1.8 to 6.9% for each of the hemoglobin species. The mean ± SD global values of HbR, HbO, HbT, StO 2 are respectively 24 ± 7 μM, 33.3 ± 9.5 μM, 57.4 ± 15.8 μM, 58 ± 4.2%. StO 2 displays the narrowest range of variability across brain regions.