Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects | Zendy

Giacomo Giacalone | Zendy; Marta Zanoletti | Zendy; Davide Contini | Zendy; Rebecca Re | Zendy; Lorenzo Spinelli | Zendy; Luisa Roveri | Zendy; Alessandro Torricelli | Zendy

Open Access

Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects

Author(s) -

Giacomo Giacalone,

Marta Zanoletti,

Davide Contini,

Rebecca Re,

Lorenzo Spinelli,

Luisa Roveri,

Alessandro Torricelli

Publication year - 2017

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.8.004987

Subject(s) - reproducibility , oxygen saturation , biomedical engineering , hemoglobin , pathology , medicine , diffuse optical imaging , saturation (graph theory) , oxygen , materials science , nuclear magnetic resonance , chemistry , radiology , mathematics , tomography , physics , chromatography , organic chemistry , combinatorics

The reproducibility of cerebral time-domain near-infrared spectroscopy (TD-NIRS) has not been investigated so far. Besides, reference intervals of cerebral optical properties, of absolute concentrations of deoxygenated-hemoglobin (HbR), oxygenated-hemoglobin (HbO), total hemoglobin (HbT) and tissue oxygen saturation (StO 2 ) and their variability have not been reported. We have addressed these issues on a sample of 88 adult healthy subjects. TD-NIRS measurements at 690, 785, 830 nm were fitted with the diffusion model for semi-infinite homogenous media. Reproducibility, performed on 3 measurements at 5 minutes intervals, ranges from 1.8 to 6.9% for each of the hemoglobin species. The mean ± SD global values of HbR, HbO, HbT, StO 2 are respectively 24 ± 7 μM, 33.3 ± 9.5 μM, 57.4 ± 15.8 μM, 58 ± 4.2%. StO 2 displays the narrowest range of variability across brain regions.

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