Open AccessIntra-ocular lens optical changes resulting from the loading of dexamethasone
Author(s) -
José María Gatell Artigas,
Mari Carmen García-Domene,
Amparo Navea,
Pablo Botella,
Eduardo Fernández
Publication year - 2017
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.8.004621
Subject(s) - dexamethasone , optical transfer function , materials science , dioptre , optics , silicone , optical power , lens (geology) , intraocular lens , biomedical engineering , medicine , composite material , visual acuity , physics , laser , endocrinology
To study the optical changes on hydrogel-silicone intraocular lenses (IOLs) resulting from loading them with dexamethasone. We used prototype hydrogel(pHEMA)-silicone IOLs and loaded the matrices with an anti-inflammatory drug (dexamethasone). The optical properties we analyzed experimentally were a) modulation transfer function (MTF); b) spectral transmission; c) diopter power. These determinations were performed on drug-loaded IOLs, IOLs that had released the drug, and IOLs that had not been drug-loaded. Loading a hydrogel-silicone IOL with dexamethasone results in impairment of its optical qualities, in particular its MTF and spectral transmission, but not dioptric power. However, once the drug has been released, it almost recovers its initial optical properties.