Open AccessAngiographic and structural imaging using high axial resolution fiber-based visible-light OCT
Author(s) -
Shaohua Pi,
Acner Camino,
Miao Zhang,
William O. Cepurna,
Gangjun Liu,
David Huang,
John C. Morrison,
Yali Jia
Publication year - 2017
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.8.004595
Subject(s) - optical coherence tomography , retina , nerve fiber layer , retinal , optics , materials science , image resolution , biomedical engineering , anatomy , ophthalmology , physics , biology , medicine
Optical coherence tomography using visible-light sources can increase the axial resolution without the need for broader spectral bandwidth. Here, a high-resolution, fiber-based, visible-light optical coherence tomography system is built and used to image normal retina in rats and blood vessels in chicken embryo. In the rat retina, accurate segmentation of retinal layer boundaries and quantification of layer thicknesses are accomplished. Furthermore, three distinct capillary plexuses in the retina and the choriocapillaris are identified and the characteristic pattern of the nerve fiber layer thickness in rats is revealed. In the chicken embryo model, the microvascular network and a venous bifurcation are examined and the ability to identify and segment large vessel walls is demonstrated.