Open AccessSimultaneously extracting multiple parameters via multi-distance and multi-exposure diffuse speckle contrast analysis
Author(s) -
Jialin Liu,
Hongchao Zhang,
Jian Lü,
Xiaowu Ni,
Zhonghua Shen
Publication year - 2017
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.8.004537
Subject(s) - speckle pattern , coherence (philosophical gambling strategy) , contrast (vision) , optics , scattering , computer science , biological system , physics , biology , quantum mechanics
Recent advancements in diffuse speckle contrast analysis (DSCA) have opened the path for noninvasive acquisition of deep tissue microvasculature blood flow. In fact, in addition to blood flow index αD B , the variations of tissue optical absorption μ a , reduced scattering coefficients [Formula: see text], as well as coherence factor β can modulate temporal fluctuations of speckle patterns. In this study, we use multi-distance and multi-exposure DSCA (MDME-DSCA) to simultaneously extract multiple parameters such as μ a , [Formula: see text], αD B , and β . The validity of MDME-DSCA has been validated by the simulated data and phantoms experiments. Moreover, as a comparison, the results also show that it is impractical to simultaneously obtain multiple parameters by multi-exposure DSCA (ME-DSCA).