Open AccessResolving adjacent nanophosphors of different concentrations by excitation-based cone-beam X-ray luminescence tomography
Author(s) -
Peng Gao,
Huangsheng Pu,
Junyan Rong,
Wenli Zhang,
Tianshuai Liu,
Wenlei Liu,
Yuanke Zhang,
Hongbing Lu
Publication year - 2017
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.8.003952
Subject(s) - materials science , tomography , luminescence , optics , tomographic reconstruction , excitation , iterative reconstruction , image quality , preclinical imaging , molecular imaging , inverse problem , biomedical engineering , physics , in vivo , optoelectronics , computer science , radiology , mathematics , image (mathematics) , medicine , artificial intelligence , mathematical analysis , microbiology and biotechnology , quantum mechanics , biology
Cone-beam X-ray luminescence computed tomography (CB-XLCT) has been proposed as a new molecular imaging modality recently. It can obtain both anatomical and functional tomographic images of an object efficiently, with the excitation of nanophosphors in vivo or in vitro by cone-beam X-rays. However, the ill-posedness of the CB-XLCT inverse problem degrades the image quality and makes it difficult to resolve adjacent luminescent targets with different concentrations, which is essential in the monitoring of nanoparticle metabolism and drug delivery. To address this problem, a multi-voltage excitation imaging scheme combined with principal component analysis is proposed in this study. Imaging experiments performed on physical phantoms by a custom-made CB-XLCT system demonstrate that two adjacent targets, with different concentrations and an edge-to-edge distance of 0 mm, can be effectively resolved.