Looking inside the heart: a see-through view of the vascular tree | Zendy

Imke Nehrhoff | Zendy; Jorge Ripoll | Zendy; Rafael Samaniego | Zendy; Manuel Desco | Zendy; María Victoria GómezGaviro | Zendy

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Looking inside the heart: a see-through view of the vascular tree

Author(s) -

Imke Nehrhoff,

Jorge Ripoll,

Rafael Samaniego,

Manuel Desco,

María Victoria GómezGaviro

Publication year - 2017

Publication title -

biomedical optics express

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.362

H-Index - 86

ISSN - 2156-7085

DOI - 10.1364/boe.8.003110

Subject(s) - visualization , computer science , tree (set theory) , computer vision , biomedical engineering , arterial tree , pathology , artificial intelligence , medicine , cardiology , mathematical analysis , mathematics

The ability to acquire 3D images of the heart and its vasculature at cellular resolution facilitates a more detailed study of many heart diseases. Here, we describe a novel technique to image in 3D the heart vasculature by combining the CUBIC clearing protocol combined with in vivo administration of fluorescent-labeled lectin. The use of these techniques in combination with S elective P lane I llumination M icroscopy (SPIM) made it possible to obtain high resolution 3D images of the cardiac vascular tree. This methodological approach may enhance the visualization of 3D images of the cardiac vasculature remodeling associated with coronary disease.

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